FeCl3·6H2O-Catalyzed Conversion of Acylals to Dihydropyrimidinones Under Microwave Conditions: A New Procedure for the Biginelli Reaction

Author： Majd Mahdieh Mozaffari   Saidi Kazem   Khabazzadeh Hojatollah  

Publisher： Taylor & Francis Ltd

ISSN： 1042-6507

Source： Phosphorus, Sulfur, and Silicon and the Related Elements, Vol.185, Iss.2, 2010-02, pp. : 325-329

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Abstract

FeCl3·6H2O efficiently catalyzed the three-component condensation reaction of acylals, ethyl acetoacetate, and urea or thiourea to afford the corresponding 3,4-dihydropyrimidin-2(1H)-ones in good yields under solvent-free and microwave conditions.

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