Controlled Release of Covalently Bound Organic Molecules by Slow Hydrolysis for Potential Biocide Applications†

Author： Mosurkal Ravi Kumar Jayant Parmar Virinder Watterson Arthur

ISSN： 1060-1325

Source： Journal of Macromolecular Science, Part A: Pure and Applied Chemistry, Vol.44, Iss.12, 2007-12, pp. : 1289-1292

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Abstract

A study of the slow hydrolysis of labile acetal groups by low concentrations of lactic acid to release the active molecules is reported. A prototype molecule containing cyclic acetal groups, dimethyl-2,3-O-benzylidene-L-tartrate (DMTAc) and the same molecule incorporated as a pendant group in a polyamide were studied for their hydrolysis by low concentrations of lactic acid. The release of benzaldehyde during slow hydrolysis is monitored by UV-vis and 1H-NMR spectroscopy. This study is very useful to ultimately design and synthesize a polymer with covalently bound insecticidal/anti-microbial/anti-fungal materials for the development of controlled release formulations.