Amyloid A amyloidosis in non-infected and avian leukosis virus-C persistently infected inbred ducks

Author： Stepanets Volodymyr Vernerová Zdenka Vilhelmová Milena Geryk Josef Hejnar Jiri Svoboda Jan

ISSN： 1465-3338

Source： Avian Pathology, Vol.30, Iss.1, 2001-02, pp. : 33-42

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Abstract

The breeding history of the first inbred strain of Khaki Campbell ducks is presented. The genetic homogeneity of this strain was tested on the basis of serum amyloid A (SAA) polymorphism and it was established that it harbours only the SAA allele A, which is expressed in liver, lung and bursa of Fabricius tissues. Pathogenic changes in control and avian leukosis virus-C (ALV-C) persistently infected ducks were evaluated during the period spanning 1 to 10 months after hatching. In both groups, AA amyloidosis was revealed and characterized. In spite of the inbred nature of animals, the incidence of amyloid A deposition varied among experiments, suggesting that additional non-genetic factors are involved. Similar variation was found in ALV-C persistently infected ducks, where only in one out of three experiments was the incidence ofAA amyloidosis significantly higher than in controls.