β-Secretase (BACE1) inhibitory property of loganin isolated from Corni fructus

Author: Youn Kumju   Jeong Woo-Sik   Jun Mira  

Publisher: Taylor & Francis Ltd

ISSN: 1478-6419

Source: Natural Product Research, Vol.27, Iss.16, 2013-08, pp. : 1471-1474

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Abstract

In the course of searching for anti-dementia agents from natural products, loganin isolated from EtOAc fraction of Corni fructus possessed specific inhibitory activity against β-secretase (BACE1) with 9.2 × 10−5 M and Ki value of 5.5 × 10−5 M. Loganin exhibited less inhibitory activity to α-secretase (TACE) and other serine proteases exhibiting that it was a relatively specific inhibitor of BACE1. These novel findings suggest that loganin may be used to attenuate the progression and/or prevention of Alzheimer's disease.

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