Synthesis and Biophysical Studies of N2'-Functionalized 2'-Amino-α-L-LNA

Author: Kumar T. Santhosh   Madsen Andreas   Wengel Jesper   Hrdlicka Patrick  

Publisher: Taylor & Francis Ltd

ISSN: 1525-7770

Source: Nucleosides, Nucleotides & Nucleic Acids, Vol.26, Iss.10-12, 2007-10, pp. : 1403-1405

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Abstract

A synthetic route towards a selected set of N-acylated and N-alkylated derivatives of 2 '-amino-α-L-LNA phosphoramidite building blocks has been developed. Biophysical studies suggest that the 2-oxo-5-azabicyclo[2.2.1]heptane skeleton of 2 '-amino-α-L-LNA allows precise positioning of intercalators in the core of nucleic acid duplexes.

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