Author: Kumar T. Santhosh Madsen Andreas Wengel Jesper Hrdlicka Patrick
Publisher: Taylor & Francis Ltd
ISSN: 1525-7770
Source: Nucleosides, Nucleotides & Nucleic Acids, Vol.26, Iss.10-12, 2007-10, pp. : 1403-1405
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Abstract
A synthetic route towards a selected set of N-acylated and N-alkylated derivatives of 2 '-amino-α-L-LNA phosphoramidite building blocks has been developed. Biophysical studies suggest that the 2-oxo-5-azabicyclo[2.2.1]heptane skeleton of 2 '-amino-α-L-LNA allows precise positioning of intercalators in the core of nucleic acid duplexes.
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