Synthesis and Anti-HSV Activity of new N1-Acyclic C4 and C6-Disubstituted Pyrazolo[3,4-D]Pyrimidine Nucleosides

Author: Moukha-chafiq Omar   Taha Mohamed Labd   Mouna Abdelmalek  

Publisher: Taylor & Francis Ltd

ISSN: 1525-7770

Source: Nucleosides, Nucleotides & Nucleic Acids, Vol.26, Iss.8-9, 2007-08, pp. : 1107-1110

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Abstract

Several N1-(2-hydroxyethoxy)methyl, (4-hydroxybutyl) and (2,3-dihydroxy-1-propoxy)methyl-C4,C6-disubstituted-1H-pyrozolo[3,4-d]pyrimidines were synthesized. Some of them were evaluated against herpes simplex virus 1 and 2 replications in E6SM cells.

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