Nucleolipids as Potential Organogelators

Author: Rosemeyer Helmut   Stürenberg Eva-Maria   Herdewijn Piet  

Publisher: Taylor & Francis Ltd

ISSN: 1525-7770

Source: Nucleosides, Nucleotides & Nucleic Acids, Vol.26, Iss.8-9, 2007-08, pp. : 995-999

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Abstract

Four different series of nucleolipids or bola-nucleolipids were synthesized or re-synthesized. Most of the compounds were studied with respect to their gelation properties toward either water or aromatic, hetero-aromatic, and aliphatic hydrocarbons. Bola-nucleolipids 6 and 7 do not gelate any solvent tested, neither as sole additive nor by adding up to 10 wt% of a 1:1 mixture. The nucleolipid 22 carrying the antiviral acyclovir as a head group proved to be a potent organogelator for aromatic hydrocarbons such as toluene, but not for hetarenes, aliphatic hydrocarbons or water. The mono-tailed nucleolipid 24 exhibits excellent organogelator properties for both aromatic and aliphatic hydrocarbons. These were studied as a function of concentration and temperature.