Author： Liu Lian Jin Yoo Jin Cheol Hong Joon Hee
Publisher： Taylor & Francis Ltd
ISSN： 1525-7770
Source： Nucleosides, Nucleotides & Nucleic Acids, Vol.28, Iss.2, 2009-02, pp. : 150-164
Disclaimer: Any content in publications that violate the sovereignty, the constitution or regulations of the PRC is not accepted or approved by CNPIEC.
Abstract
An efficient route for synthesizing novel allylic and cyclopropanoid phosphonic acid nucleoside analogues is described. The condensation of the bromine derivatives 6 and 18 with nucleoside bases (A, U, T, C, G) under standard nucleophilic substitution and deprotection conditions, afforded the target phosphonic acid nucleoside analogues. These compounds were evaluated for their antiviral properties against various viruses. Cyclopropanoid phosphonic adenine nucleoside analogue 23 showed significant anti-HIV activity.
Related content
Access to resources
Recommend
Synthesis and Biological Evaluation of Acyclic Phosphonic Acid Nucleoside Derivatives
By Wainwright Philip Maddaford Adrian Zhang Xiurong Billington Helen Leese David Glen Rebecca Pryde David C. Middleton Donald S. Stephenson Peter T. Sutton Scott
Nucleosides, Nucleotides & Nucleic Acids, Vol. 32, Iss. 9, 2013-09 ,pp. :
By Kim Eunae Shen Guang Huan Hong Joon Hee
Nucleosides, Nucleotides & Nucleic Acids, Vol. 30, Iss. 10, 2011-10 ,pp. :