Toxicological Effects of Tributyltin on Physiological Function of Carassius Aurats

Author： Han Zhao-Xiang Lv Chun-Xia Li Huang

ISSN： 1553-3174

Source： Synthesis and Reactivity in Inorganic, Metal-Organic, and Nano-Metal Chemistry, Vol.39, Iss.6, 2009-07, pp. : 295-301

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Abstract

Triorganotin compounds are widely distributed toxicants. In this study, we discussed the toxicological effects of tributyltin on the physiological functions of carassius aurats. The results show that the effects of TBT on plasma membrane fluidity in leukocytes were significantly different under the different concentration (P < 0.05). The Plasma membrane fluidity increased with higher TBT concentration exposure (p < 0.05), which presents a dose-dependent manner. TBT can produce a relatively fast liberation of hemoglobin with the higher concentration; moreover, the relative hemolysis decreased when erythrocytes were in a medium in the presence of gluconate, suggesting a protective role for gluconate against TBT induced hemolysis. AchE serves as a key enzyme of nerve conduction, TBT can inhibit the AchE activity, and it demonstrates that the degree of inhibition of the acetylcholinesterase increases with the increase of the TBT concentration, which presents a dose-dependent manner, too. Enzyme activity levels for EROD showed apparent TBT concentration-dependent increases with the higher TBT concentration. In the TBT exposures, the lowest concentration of 0.1 μM had a non-significantly higher aromatase activity than controls (p < 0.05). After a spike at the 0.25 μM exposure, aromatase activity generally decreased with an increase in exposure. This shows that TBT was potent inhibitor of aromatase activity in the brain. Lactate dehydrogenase activity increased with the concentration of TBT in the medium. Based on these results, it can be suggested that TBT will affect the physiological function of carassius Aurats.