Adipose Tissue Formation in Collagen Scaffolds with Different Biodegradabilities

Author： Kimura Yu   Inamoto Takashi   Tabata Yasuhiko  

Publisher： Taylor & Francis Ltd

ISSN： 1568-5624

Source： Journal of Biomaterials Science, Polymer Edition, Vol.21, Iss.4, 2010-03, pp. : 463-476

Disclaimer: Any content in publications that violate the sovereignty, the constitution or regulations of the PRC is not accepted or approved by CNPIEC.

Previous Menu Next

Abstract

In vivo adipose tissue regeneration by preadipocytes was evaluated by combining them with collagen sponges with different biodegradabilities and gelatin microspheres incorporating basic fibroblast growth factor (bFGF) for the controlled release. The collagen sponge biodegradability was regulated from 1–4 weeks by changing the cross-linking conditions in collagen sponge preparation. The time profile of bFGF release was controlled from 1–5 weeks by the biodegradability of gelatin microspheres used. The collagen sponges combined with human preadipocytes and gelatin microspheres incorporating bFGF were implanted into the back subcutis of nude mice to evaluate the adipose tissue regeneration. The regeneration of adipose tissue was observed in every collagen sponge. The area of regenerated adipose tissue was maximal in the collagen sponge with a degradation time of 2 weeks. No influence of the time profile of bFGF release on the area of regenerated adipose tissue was detected.

Related content

Electrospun PHBV/collagen composite nanofibrous scaffolds for tissue engineering

By Meng Wan   Kim Se-Yong   Yuan Jiang   Kim Jung Chul   Kwon Oh Hyeong   Kawazoe Naoki   Chen Guoping   Ito Yoshihiro   Kang Inn-Kyu  

Journal of Biomaterials Science, Polymer Edition, Vol. 18, Iss. 1, 2007-01 ,pp. : 81-94 (14)

Taylor & Francis Ltd

Access to resources Recommend Favorite

Flow Perfusion Improves Seeding of Tissue Engineering Scaffolds with Different Architectures

By Alvarez-Barreto Jose   Linehan Shawna   Shambaugh Robert   Sikavitsas Vassilios  

Annals of Biomedical Engineering, Vol. 35, Iss. 3, 2007-03 ,pp. : 429-442 (14)

Springer Publishing Company

Access to resources Recommend Favorite

Hyaluronan and Fibrin Biomaterial as Scaffolds for Neuronal Differentiation of Adult Stem Cells Derived from Adipose Tissue and Skin

By Gardin Chiara   Vindigni Vincenzo   Bressan Eriberto   Ferroni Letizia   Nalesso Elisa   Puppa Alessandro Della   D’Avella Domenico   Lops Diego   Pinton Paolo   Zavan Barbara  

International Journal of Molecular Sciences, Vol. 12, Iss. 10, 2011-10 ,pp. : 6749-6764 (16)

MDPI

Access to resources Recommend Favorite

Tannic Acid Cross-linked Collagen Scaffolds and Their Anti-cancer Potential in a Tissue Engineered Breast Implant

By Cass Cheryl A. P.   Burg Karen J. L.  

Journal of Biomaterials Science, Polymer Edition, Vol. 23, Iss. 1-4, 2012-01 ,pp. : 281-298 (18)

Taylor & Francis Ltd

Access to resources Recommend Favorite

Development of Collagen/Demineralized Bone Powder Scaffolds and Periosteum-Derived Cells for Bone Tissue Engineering Application

By Thitiset Thakoon   Damrongsakkul Siriporn   Bunaprasert Tanom   Leeanansaksiri Wilairat   Honsawek Sittisak  

International Journal of Molecular Sciences, Vol. 14, Iss. 1, 2013-01 ,pp. : 2056-2071 (16)

MDPI

Access to resources Recommend Favorite