Publisher： John Wiley & Sons Inc
ISSN： 1433-7851
Source： ANGEWANDTE CHEMIE INTERNATIONAL EDITION, Vol.54, Iss.13, 2015-03, pp. : 4023-4027
Disclaimer: Any content in publications that violate the sovereignty, the constitution or regulations of the PRC is not accepted or approved by CNPIEC.
Abstract
Catalytic α‐alkylation of esters with primary alcohols is a desirable process because it uses low‐toxicity agents and generates water as the by‐product. Reported herein is a NCP pincer/Ir catalyst which is highly efficient for α‐alkylation of a broad scope of unactivated esters under mild reaction conditions. For the first time, alcohols alkylate unactivated α‐substituted acyclic esters, lactones, and even methyl and ethyl acetates. This method can be applied to the synthesis of carboxylic acid derivatives with diverse structures and functional groups, some of which would be impossible to access by conventional enolate alkylations with alkyl halides.
Related content
A General and Mild Catalytic α‐Alkylation of Unactivated Esters Using Alcohols
ANGEWANDTE CHEMIE, Vol. 127, Iss. 13, 2015-03 ,pp. :
Access to resources
Recommend
Iron‐Catalyzed α‐Alkylation of Ketones with Alcohols
ANGEWANDTE CHEMIE, Vol. 127, Iss. 48, 2015-11 ,pp. :
Iron‐Catalyzed α‐Alkylation of Ketones with Alcohols
ANGEWANDTE CHEMIE INTERNATIONAL EDITION, Vol. 54, Iss. 48, 2015-11 ,pp. :
Silver Hexafluoroantimonate‐Catalyzed Direct α‐Alkylation of Unactivated Ketones
ADVANCED SYNTHESIS & CATALYSIS, Vol. 357, Iss. 7, 2015-05 ,pp. :
Direct α‐Alkylation of Aldehydes by Brønsted‐Acid Catalysis
CHINESE JOURNAL OF CHEMISTRY (ELECTRONIC), Vol. 30, Iss. 1, 2012-01 ,pp. :