Publisher： John Wiley & Sons Inc
ISSN： 1433-7851
Source： ANGEWANDTE CHEMIE INTERNATIONAL EDITION, Vol.54, Iss.13, 2015-03, pp. : 3830-3830
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Abstract
Nanocarriers for the delivery of hydrophilic reagents are important in drug therapy and disease diagnosis. In their Communication on page 3952 ff., J. Sun, X. Jiang, and co‐workers report a three‐stage microfluidic chip that can assemble water core/PLGA shell/lipid layer rigid nanovesicles (RNV) in one step for hydrophilic‐reagent delivery (PLGA=poly(lactic‐co‐glycolic acid)). For a multi‐drug‐resistant tumor model, co‐delivery of siMDR1 and doxorubicin using RNVs has an enhanced antitumor effect in both in vitro and in vivo experiments.
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