Inside Cover: Microfluidic Synthesis of Rigid Nanovesicles for Hydrophilic Reagents Delivery (Angew. Chem. Int. Ed. 13/2015)

Publisher: John Wiley & Sons Inc

ISSN: 1433-7851

Source: ANGEWANDTE CHEMIE INTERNATIONAL EDITION, Vol.54, Iss.13, 2015-03, pp. : 3830-3830

Disclaimer: Any content in publications that violate the sovereignty, the constitution or regulations of the PRC is not accepted or approved by CNPIEC.

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Abstract

Nanocarriers for the delivery of hydrophilic reagents are important in drug therapy and disease diagnosis. In their Communication on page 3952 ff., J. Sun, X. Jiang, and co‐workers report a three‐stage microfluidic chip that can assemble water core/PLGA shell/lipid layer rigid nanovesicles (RNV) in one step for hydrophilic‐reagent delivery (PLGA=poly(lactic‐co‐glycolic acid)). For a multi‐drug‐resistant tumor model, co‐delivery of siMDR1 and doxorubicin using RNVs has an enhanced antitumor effect in both in vitro and in vivo experiments.