

Publisher: John Wiley & Sons Inc
ISSN: 1433-7851
Source: ANGEWANDTE CHEMIE INTERNATIONAL EDITION, Vol.54, Iss.13, 2015-03, pp. : 3830-3830
Disclaimer: Any content in publications that violate the sovereignty, the constitution or regulations of the PRC is not accepted or approved by CNPIEC.
Abstract
Nanocarriers for the delivery of hydrophilic reagents are important in drug therapy and disease diagnosis. In their Communication on page 3952 ff., J. Sun, X. Jiang, and co‐workers report a three‐stage microfluidic chip that can assemble water core/PLGA shell/lipid layer rigid nanovesicles (RNV) in one step for hydrophilic‐reagent delivery (PLGA=poly(lactic‐co‐glycolic acid)). For a multi‐drug‐resistant tumor model, co‐delivery of siMDR1 and doxorubicin using RNVs has an enhanced antitumor effect in both in vitro and in vivo experiments.
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