Direct Peptide Lipidation through Thiol–Ene Coupling Enables Rapid Synthesis and Evaluation of Self‐Adjuvanting Vaccine Candidates

Publisher： John Wiley & Sons Inc

ISSN： 0044-8249

Source： ANGEWANDTE CHEMIE, Vol.125, Iss.40, 2013-09, pp. : 10810-10813

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Abstract

Eine radikal(isch)e Lipidierung: Eine neue Thiol‐En‐Lipidierung ermöglicht die einstufige Synthese von antigenen Peptiden mit Eigenverstärkungseffekt als Impfstoffkandidaten. Es wird gezeigt, dass die erhaltenen Monoacyllipopeptide Monocyten aktivieren.

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