Expression of glucocorticoid receptor-α in the epidermis of patients with psoriasis vulgaris

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E-ISSN： 1792-1015|10|2|419-422

ISSN： 1792-0981

Source： Experimental and Therapeutic Medicine, Vol.10, Iss.2, 2015-01, pp. : 419-422

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Abstract

Expression of glucocorticoid receptor (GR)-α is observed in almost all tissues and cells of the body; thus, investigating the expression of the receptor in the epidermis of patients with psoriasis vulgaris. The aim of the present study was to investigate GRα expression in the epidermis of psoriasis vulgaris patients The study population consisted of 26 patients with psoriasis vulgaris and 10 normal control cases. None of the patients had received any prior treatment with glucocorticoids. Epithelial tissue samples were detected using a streptavidin peroxidationenzymatic method for biopsy. Nonlesional tissue samples from within a range of 3 cm of lesions formed the nonlesional group, and lesional tissue samples formed the lesional group. Pathological image analysis system (named CMIAS) was used to convert image signals into numeric values, according to the optical density per unit area. GRα expression was observed within the nucleus in the normal control group; however, cytoplasmic expression was observed in the lesions of the psoriatic group. The optical density values were significantly lower in the psoriatic group when compared with the normal control group, indicating a statistically significant difference in GRα expression between the two groups (P<0.001), and this decreasing correlation was unaffected by the administration of steroids for 6 months. Therefore, decreased expression of GRα may play an important role in the degeneration of keratinocytes in patients with psoriasis vulgaris.