miRNA-1207-5p is associated with cancer progression by targeting stomatin-like protein 2 in esophageal carcinoma

Author： Yang Xuan Zang Wenqiao Xuan Xiaoyan Wang Zhongquan Liu Zhicai Wang Jinwu Cui Jing Zhao Guoqiang

E-ISSN： 1791-2423|46|5|2163-2171

ISSN： 1019-6439

Source： International Journal of Oncology, Vol.46, Iss.5, 2015-05, pp. : 2163-2171

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Abstract

Newly discovered intrinsic regulators, the miRNAs regulate gene expression by binding to the 3'-untranslated regions of the genome. Accumulating studies have indicated that miRNAs are aberrantly expressed in various human cancers. We found that miRNA-1207-5p (miR1207-5p) was markedly downregulated in esophageal carcinoma (EC) tissues, and was correlated with EC differentiation, pathological stage and lymph node metastasis. Rates of apoptosis were increased and cell invasion ability was decreased in EC9706 and EC-1 cells transfected with a miR1207-5p mimic. Stomatin-like protein 2 (STOML-2) was predicted to be a potential target of miR1207-5p by bioinformatics analysis and this was confirmed by luciferase assay and western blotting. Our study showed that STOML-2 was negatively regulated by miR1207-5p. Furthermore, overexpression of STOML-2 abolished the miR1207-5p anti-invasion function. Based on these results, we proposed that miR1207-5p might act as a potential therapeutic target in the treatment of EC.