Publisher： Bentham Science Publishers
E-ISSN： 1875-5992|15|6|783-792
ISSN： 1871-5206
Source： Anti-Cancer Agents in Medicinal Chemistry (Formerly Current Medicinal Chemistry - Anti-Cancer Agents), Vol.15, Iss.6, 2015-07, pp. : 783-792
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Abstract
The new complex of {[Co(4,4′-Bipy)(H2O)4]·(Pyri)·3H2O}n (4,4′-Bipy = 4,4′-bipyridyl, H2Pyri = 3,5- Pyridinedicarboxylic acid) was synthesized and characterized by IR, element analysis and X-ray single-crystal diffraction. The binding of the complex with extracted HeLa cells DNA was investigated by UV and fluorescence spectrum. Gel electrophoresis assay demonstrated the ability of the complex cleaving the extracted HC-DNA. The complex exhibited a higher cytotoxicity against tumor cells in vitro. Furthermore, the apoptotic tests indicated the complex had an apoptotic effect on HeLa cells.
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