Publisher： Bentham Science Publishers
E-ISSN： 1874-4729|1|2|122-124
ISSN： 1874-4710
Source： Current Radiopharmaceuticals, Vol.1, Iss.2, 2008-05, pp. : 122-124
Disclaimer: Any content in publications that violate the sovereignty, the constitution or regulations of the PRC is not accepted or approved by CNPIEC.
Abstract
Synthesis of L-[3-13C]tryptophan (2) from N,N-dimethyl[13C]formamide (4) and Dellaria's oxazinone 1 as a chiral glycine equivalent was achieved. Vilsmeier reaction of indole (5) and N,N-dimethyl[13C]formamide (4) afforded a good yield of indole-3-[13C]carbaldehyde (3), which was converted to the bromide 8. Diastereoselective alkylation of the enolate of 1 with the bromide 8 proceeded with high diastereoselectivity to give 9. Ethanolysis, hydrogenolysis and hydrolysis of 9 gave L-[3-13C]tryptophan (2).
Related content
By Tohyama Y. Yamane F. Merid M.F. Diksic M.
European Neuropsychopharmacology, Vol. 11, Iss. 3, 2001-06 ,pp. :
Access to resources
Recommend
By Dougherty Donald Marsh-Richard Dawn Mathias Charles Hood Ashley Addicott Merideth Moeller F. Morgan Christopher Badawy Abdulla
Psychopharmacology, Vol. 198, Iss. 3, 2008-06 ,pp. :
Asymmetric Total Synthesis of Ieodomycin B
By Lin Shuangjie Zhang Jianting Zhang Zhibin Xu Tianxiang Huang Shuangping Wang Xiaoji
Marine Drugs, Vol. 15, Iss. 1, 2017-01 ,pp. :
Access to resources