MicroRNA-34a: Role in Cancer and Cardiovascular Disease

Publisher: Bentham Science Publishers

E-ISSN: 1873-5592|15|4|361-373

ISSN: 1389-4501

Source: Current Drug Targets, Vol.15, Iss.4, 2014-04, pp. : 361-373

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Abstract

Small non-coding microRNAs (miRNAs) regulate gene expression at the post-transcriptional and translational levels. The dysregulated miRNAs are involved in a large variety of diseases including cancer and cardiovascular diseases. MiR-34a is one of the most anti-oncomiRs that is down-regulated in multiple types of cancer. It regulates a wide range of genes and pathways involved in cancer initiation, progression and metastasis. Next to cancer, miR-34a is recently found to be implicated in cardiovascular disease as one damager factor. In this review, we highlight the complex roles of miR-34a in cancer and cardiovascular disease, as well as the therapeutic potentials.