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Synthesis of Marine Natural Products with Antimalarial Activity

Publisher: Bentham Science Publishers

E-ISSN: 1875-5607|8|12|1265-1284

ISSN: 1389-5575

Source: Mini Reviews in Medicinal Chemistry, Vol.8, Iss.12, 2008-10, pp. : 1265-1284

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Abstract

The role played by synthetic organic chemistry of marine metabolites as potential leads for drug discovery of antimalarial agents is discussed. Syntheses of the most promising molecules are summarized, with emphasis on structureactivity relationship (SAR) studies and their mechanism of action.