Publisher： Bentham Science Publishers
E-ISSN： 1875-628x|8|9|857-860
ISSN： 1570-1808
Source： Letters in Drug Design & Discovery, Vol.8, Iss.9, 2011-11, pp. : 857-860
Disclaimer: Any content in publications that violate the sovereignty, the constitution or regulations of the PRC is not accepted or approved by CNPIEC.
Abstract
To search for potential anti-cancer analogs, 16 aromatic esters of 4'-demethyl-4-deoxypodophyllotoxin (6a-p) were synthesized and tested their cytotoxicity on six cancer cell lines. The results indicated that all derivatives showed potent cytotoxic activity against A-549 cell line with IC50 values of 0.00009-0.037 μg/mL.
Related content
Access to resources
Recommend
Synthesis and study of some 4-aza and 17a-azasteroidal isoxazoles
By Gupta R. Pathak D. Jindal D.P.
European Journal of Medicinal Chemistry, Vol. 34, Iss. 7, 1999-07 ,pp. :
Inhibition of Endotoxin Response by Synthetic TLR4 Antagonists
Current Topics in Medicinal Chemistry, Vol. 4, Iss. 11, 2004-07 ,pp. :
Neuromuscular blocking activity of bis-4-benzyltetrahydroisoquinolinium esters in the cat
By Beijing-Paris-Rome-Saclay BPRS Bacci C. Belli P. Bernabei R. Dai C.J. Di Nicolantonio W. Ding L.K. Gaillard-Lecanu E. Gerbier G. Giraud-Heraud Y. H. H.K. Incicchitti A. Landoni V. Mallet J. Mosca L. Prosperi D. Tao C. Patel S.S. Maehr R.B. Wastila W.B. Savarese J.J. Wisowaty J.C.
European Journal of Pharmaceutical Sciences, Vol. 4, Iss. 2, 1996-03 ,pp. :