Publisher： Bentham Science Publishers
E-ISSN： 1875-6638|8|5|985-989
ISSN： 1573-4064
Source： Medicinal Chemistry, Vol.8, Iss.5, 2012-09, pp. : 985-989
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Abstract
A simple and practical synthetic approach for tasigna was described here in six steps with high yield (40%). All of the intermediates and final target compound were isolated cleanly in high yield without a need for chromatographic purification. Significantly, the facile synthetic route proposed in this work has the characteristics of mild synthetic conditions, inexpensive reagents, high yield and simple operation.
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