Publisher： Bentham Science Publishers
E-ISSN： 1874-4702|3|3|164-173
ISSN： 1874-4672
Source： Current Molecular Pharmacology, Vol.3, Iss.3, 2010-11, pp. : 164-173
Disclaimer: Any content in publications that violate the sovereignty, the constitution or regulations of the PRC is not accepted or approved by CNPIEC.
Abstract
Devising therapies for neurodegenerative diseases remains a major challenge due to the complex etiology, prolonged disease course and the paucity of validated targets. These factors make it difficult to model neurodegenerative diseases in a manner amenable to large-scale screening. However, recent developments in automation, combinatorial chemistry and high-throughput phenotypic assays have presented new opportunities for discovering small molecule therapeutics for neurodegenerative diseases. This review focuses on novel in vitro and phenotypic screens for Huntington's disease and a few other neurodegenerative diseases. The lessons learned from these screens and the potential of the small molecules identified as therapeutic leads are discussed.
Related content
Tocopherol (Vitamin E) in Alzheimers Disease and Other Neurodegenerative Disorders
CNS Drugs, Vol. 18, Iss. 12, 2004-01 ,pp. :
Access to resources
Recommend
Emerging drug therapies in Huntington's disease
By Mason Sarah L Barker Roger A
Expert Opinion on Emerging Drugs, Vol. 14, Iss. 2, 2009-06 ,pp. :
By Trojanowski John Q Smith Amos B Huryn Donna Lee Virginia M-Y
Expert Opinion on Pharmacotherapy, Vol. 6, Iss. 5, 2005-05 ,pp. :