Roles of Nitric Oxide Synthase inhibitor on Antinociceptive Effects of μ-Opioid Agonist in Mice

Publisher： Bentham Science Publishers

E-ISSN： 1875-5305|13|10|993-997

ISSN： 0929-8665

Source： Protein and Peptide Letters, Vol.13, Iss.10, 2006-10, pp. : 993-997

Disclaimer: Any content in publications that violate the sovereignty, the constitution or regulations of the PRC is not accepted or approved by CNPIEC.

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Abstract

In the present study, it was found that intraperitoneal (i.p.) pre-injection of NG-nitro-L-arginine methyl ester (LNAME) significantly influenced the endomorphin-1 (EM-1) and endomorphin-2 (EM-2) induced antinociception. These effects could be inhibited or reversed by L-Arg or naloxone. Our results suggest that the modulatory effect of NO system on the mu-receptor evoked analgesia is different between the two mu receptor subtypes.

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