The Use of a Supported Base and Strong Cation Exchange (SCX) Chromatography to Prepare a Variety of Structurally-Diverse Molecular Libraries Prepared by Solution-Phase Methods

Publisher: Bentham Science Publishers

E-ISSN: 1875-5402|5|3|211-218

ISSN: 1386-2073

Source: Combinatorial Chemistry & High Throughput Screening, Vol.5, Iss.3, 2002-05, pp. : 211-218

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Abstract

The preparation of molecular libraries of aminomethylbiaryls, allylic amines, and ethanolamines using solution-phase methodology is described. In particular, the use of a solid-supported base reagent (PTBD resin) and strong cation exchange(SCX) resin to effect ‘catch and release’ purification across these diverse libraries is highlighted.