Enantioselective Transfer Reaction of Phenyl to Aldehydes Using LProline- Derived Amino Alcohols as Chiral Ligands

Publisher: Bentham Science Publishers

E-ISSN: 1875-6255|11|5|356-360

ISSN: 1570-1786

Source: Letters in Organic Chemistry, Vol.11, Iss.5, 2014-06, pp. : 356-360

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Abstract

((S)-1-(1,3,5-trimethyl)benzylpyrrolidin-2-yl)diphenylmethanol (1d) was found to be an effective chiral ligand in the asymmetric transfer reaction of phenyl to aldehydes to give the corresponding adducts in excellent enantioselectivity (up to 98% ee) with very high yields (up to 99%).

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