Aza-Michael Addition of Amines to Activated Alkenes Catalyzed by Silica Supported Perchloric Acid Under a Solvent-Free Condition

Publisher: Bentham Science Publishers

E-ISSN: 1875-6255|4|1|54-59

ISSN: 1570-1786

Source: Letters in Organic Chemistry, Vol.4, Iss.1, 2007-01, pp. : 54-59

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Abstract

An efficient aza-Michael addition of amines to a series of ,&bgr;-unsaturated ketones, carboxylic esters, nitriles and chalcones has been carried out using perchloric acid supported over silica gel (HClO4-SiO2) at room temperature in high yields under solvent-free reaction conditions.