Publisher： Bentham Science Publishers
E-ISSN： 1875-5607|10|1|20-31
ISSN： 1389-5575
Source： Mini Reviews in Medicinal Chemistry, Vol.10, Iss.1, 2010-01, pp. : 20-31
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Abstract
Many therapeutic reagents for hepatitis B virus infection have established efficacy in goals such as alanine aminotransferase normalization, hepatitis B virus DNA suppression, HBeAg seroconversion, histological improvement, and reduce disease progression. However, it is not established that the efficacy of these reagents for the long-term survival and prevention of hepatocellular carcinoma although recent meta-analyses have also shown antiviral therapy to be efficacious. This article reviews the current status and innovative new options for antiviral therapy for hepatitis B and also discusses the various mechanisms of action for each drug, the results of clinical studies for each therapy, and the problems yet to be solved with respect to hepatitis B treatment.
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