Design and Synthesis of Novel Chemokine Analogs Derived from vMIP-II

Publisher： Bentham Science Publishers

E-ISSN： 1875-5305|13|5|499-501

ISSN： 0929-8665

Source： Protein and Peptide Letters, Vol.13, Iss.5, 2006-05, pp. : 499-501

Disclaimer: Any content in publications that violate the sovereignty, the constitution or regulations of the PRC is not accepted or approved by CNPIEC.

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Abstract

Stepwise solid phase synthesis using the Fmoc chemistry is reported for a panel of 71-residue and novel unnatural chemokine analogs derived from vMIP-II. This demonstrates the feasibility of using this synthetic method to generate de novo designed protein ligand molecules to study the biology and pharmacology of chemokine receptors.

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