Phenylpyazoleanilides as a Potent Inhibitor of IL-15 Dependent T Cell Proliferation. Part 1: A New Class of Orally Available Immunomodulators

Publisher: Bentham Science Publishers

E-ISSN: 1875-628x|5|2|111-115

ISSN: 1570-1808

Source: Letters in Drug Design & Discovery, Vol.5, Iss.2, 2008-03, pp. : 111-115

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Abstract

In research for a new immunomodulator, we discoverd a novel hydroxypiperidine derivative 9h which was a potent inhibitor of IL-15induced T cell activation. Further modification of 9h gave a potent and orally active agent 10 which was effective in a mouse CIA model.