Publisher： Bentham Science Publishers
E-ISSN： 1875-5488|6|8|609-611
ISSN： 1389-2029
Source： Current Genomics, Vol.6, Iss.8, 2005-12, pp. : 609-611
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Abstract
Apoptosis, the cell's intrinsic death program, plays an important role in the regulation of tissue homeostasis. Also, killing of cancer cells by various cytotoxic approaches such as anticancer drugs, &ggr;-irradiation, suicide genes or immunotherapy, is predominantly mediated through induction of apoptosis in target cells. Understanding the molecular events that regulate apoptosis and how tumor cells evade apoptotic deletion have provided a paradigm to link cancer genetics and response to cancer therapy. Thus, insights into the mechanisms regulating drug-induced apoptosis provide rational targets for novel therapeutic interventions.
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