Application of In-Line Liquid Chromatography-Accurate Radioisotope Counting-Mass Spectrometry (LC-ARC-MS) to Evaluate Metabolic Profile of [3H]-Mefenamic Acid in Rat Plasma

Publisher： Bentham Science Publishers

E-ISSN： 1874-0758|1|3|179-188

ISSN： 1872-3128

Source： Drug Metabolism Letters, Vol.1, Iss.3, 2007-08, pp. : 179-188

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Abstract

Profiling of rat plasma using a highly sensitive LC-ARC-MS technique showed that [3H] mefenamic acid was metabolized to several products, including a sulfate conjugate and a hydroxylated analogue as major metabolites. This technique of detecting low levels of radioactivity in plasma was superior to previously used methods, such as &bgr;-RAM detectors.

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