Publisher： Bentham Science Publishers
E-ISSN： 1875-533x|10|12|1051-1064
ISSN： 0929-8673
Source： Current Medicinal Chemistry, Vol.10, Iss.12, 2003-06, pp. : 1051-1064
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Abstract
Deferiprone, a hydroxypyridin-4-one, is effective at facilitating iron removal from iron overloaded patients, when administered orally. Some problems associated with deferiprone are discussed. Hydroxypyridinone analogues with improved distribution, metabolism and affinity for iron are described. In particular the “high pFe3+”hydroxypyridin-4-ones possess considerable clinical potential.
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