Publisher： Bentham Science Publishers
E-ISSN： 1875-631x|6|4|272-272
ISSN： 1573-3955
Source： Current Immunology Reviews, Vol.6, Iss.4, 2010-11, pp. : 272-272
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Abstract
This issue covers scientist-knowledge from different disciplines such as: immunology, neuroscience, endocrinology, pharmacology, psychiatry, biochemistry, oncology and infectology. Increasing research recognizes the importance of integrating and/or overlapping this borderline areas.Papers reflect advances in detailed immunological areas, like the impact of different variables on specific humoral, cellular and molecular events, that take place over the course of autoimmune, inflammatory, neural and endocrine responses and infection diseases. Also, manuscripts presented in this volume, indicate a clearly immunomodulatory role of thyroid hormones, gonadal hormones in addition to the glucocorticoids. The recognition of defects in cells of the innate system of aged individuals and the understanding of their consequences will help in the development of better therapeutic strategies for the elderly is analyzed.More emphasis is placed on the immunomodulatory role of neurotransmitter autoantibodies in immunophatological mechanisms. Furthermore, the molecular mechanism of action of sympathetic, parasimphatetic and histaminergic mediators are studied at increasing detailed levels, to gain understanding in the role that, second messengers, such as nitric oxide, prostaglandins, cGMP, cAMP and cytokines play in the transduction of their effects.The very innovative and interesting modulatory role of immune system in central cognitive processes (learning and memory), also has a place in this issue.Moreover, the range of diseases in which neural - immune mechanism are being studied has greatly expanded, from non traditional autoimmune diseases such as schizophrenia, depression and diabetes. Elucidation of immunological and inflammatory factors in the pathogenesis of this illnesses are in deep detailed in the present issue. In this context, recent evidence has shed light to an emerging role of protein-glycan interactions in the regulation of immune cell biology; and we integrate traditional and novel subsets of immune cells and will highlight the relevance of protein-glycan systems in modulating their physiology.Indeed, this issue represents a beginning of integration of immunology with other disciplines. Here, papers reflect studies of molecular mechanism, pharmacological and endocrine pathways to clinical relevant immune interaction, in health and diseases.
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