Peptide Backbone Modifications

Publisher： Bentham Science Publishers

E-ISSN： 1875-5348|12|5|355-385

ISSN： 1385-2728

Source： Current Organic Chemistry, Vol.12, Iss.5, 2008-03, pp. : 355-385

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Abstract

The selective introduction or manipulation of side chains in a peptide represents a severe synthetic challenge. During the last years numerous different approaches towards the targeted modification of small to medium-sized peptides have been developed which should be presented in this review. Focusing on the manipulation of the peptide backbone, procedures concerning selective N-alkylation, C-alkylation and Cequals;O-thionation are described.

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