Structure Diversity, Synthesis, and Biological Activity of Cyathane Diterpenoids in Higher Fungi

Publisher: Bentham Science Publishers

E-ISSN: 1875-533x|22|19|2375-2391

ISSN: 0929-8673

Source: Current Medicinal Chemistry, Vol.22, Iss.19, 2015-06, pp. : 2375-2391

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Abstract

Cyathane diterpenoids, occurring exclusively in higher basidiomycete (mushrooms), represent a structurally diverse class of natural products based on a characteristic 5-6-7 tricyclic carbon scaffold, including 105 members reported to date. These compounds show a diverse range of biological activities, such as antimicrobial, anti-MRSA, agonistic toward the kappa-opioid receptor, antiinflammatory, anti-proliferative and nerve growth factor (NGF)-like properties. The present review focuses on the structure diversity, structure elucidation and biological studies of these compounds, including mechanisms of actions and structure-activity relationships (SARs). In addition, new progress in chemical synthesis of cyathane diterpenoids is discussed.