Publisher： Bentham Science Publishers
E-ISSN： 1875-5992|13|10|1582-1589
ISSN： 1871-5206
Source： Anti-Cancer Agents in Medicinal Chemistry (Formerly Current Medicinal Chemistry - Anti-Cancer Agents), Vol.13, Iss.10, 2013-12, pp. : 1582-1589
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Abstract
Twenty six compounds (coumarins, flavonoids and alkaloids) were evaluated for their ability to inhibit the growth of three human tumor cell lines: breast adenocarcinoma (MCF-7), non-small cell lung cancer (NCI-H460) and melanoma (A375-C5). Three of them [3-hydroxyflavone (6), 2’-hydroxy-3,4,4’,5,6’-pentamethoxychalcone (11), Siderin (20)] were very potent in inhibiting all human tumor cell lines tested. The structure / activity relationship is discussed.
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