Publisher： Bentham Science Publishers
E-ISSN： 1873-4286|20|8|1268-1273
ISSN： 1381-6128
Source： Current Pharmaceutical Design, Vol.20, Iss.8, 2014-03, pp. : 1268-1273
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Abstract
We briefly discuss recent progress in computational characterization of the sequence and structural properties of &bgr;-barrel membrane properties. We discuss the emerging concept of weakly stable regions in &bgr;-barrel membrane proteins, computational methods to identify these regions and mechanisms adopted by &bgr;-barrel membrane proteins in nature to stabilize them. We further discuss computational methods to identify protein-protein interactions in &bgr;-barrel membrane proteins and recent experimental studies that aim at altering the biophysical properties including oligomerization state and stability of &bgr;-barrel membrane proteins based on the emerging organization principles of these proteins from recent computational studies.
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