Publisher： Bentham Science Publishers
E-ISSN： 1875-628x|11|2|150-155
ISSN： 1570-1808
Source： Letters in Drug Design & Discovery, Vol.11, Iss.2, 2014-02, pp. : 150-155
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Abstract
Divalent ligand provides a special approach for designing bioactive molecules. Aiming at searching for novel insecticidal divalent neonicotinoid insecticides, bis-phenylazoneonicotinoids were designed and synthesized here using nitromethylene analogue of imidacloprid, diazo unit and benzene system as pharmacophore, linker and spacer, respectively. The designed divalent compounds exhibited moderate insecticidal activity against cowpea aphids (Aphis craccivora).
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