Publisher： Bentham Science Publishers
E-ISSN： 1875-628x|11|2|211-221
ISSN： 1570-1808
Source： Letters in Drug Design & Discovery, Vol.11, Iss.2, 2014-02, pp. : 211-221
Disclaimer: Any content in publications that violate the sovereignty, the constitution or regulations of the PRC is not accepted or approved by CNPIEC.
Abstract
In different RNA viruses, the nucleocapsid protein N (N protein) plays an important functional role by enwrapping the viral genomic RNA in an RNase-resistant form. Targeting this essential protein is one of the best methods to find novel Chandipura virus (CHPV) inhibitors. The model of N protein of CHPV showed that this protein bears an alpha helical type topology. Computational characterization of N protein of CHPV exhibited that it bears DNA/ RNA binding region. Among all of the computationally screened compounds by GOLD, Flex X and ligandfit (DSv2.5) programs, antiviral compounds such as nelfinavir, acyclovir, azidothymidine are having very high binding affinity towards N protein of CHPV.
Related content
Access to resources
Recommend
Quantum mechanical effect in protein–ligand interaction
Expert Opinion on Drug Discovery, Vol. 5, Iss. 1, 2010-01 ,pp. :