Hologram QSAR Studies of N,N-Dialkyl-2-phenylindol-3-ylglyoxylamides Derivatives as Selective Peripheral Benzodiazepine Receptor Ligands

Publisher： Bentham Science Publishers

E-ISSN： 1875-628x|7|2|133-138

ISSN： 1570-1808

Source： Letters in Drug Design & Discovery, Vol.7, Iss.2, 2010-02, pp. : 133-138

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Abstract

Peripheral benzodiazepine receptor (PBR) is an important target for the development of drugs to treat anxiety and sleep disorders. Hologram QSAR models were built for good statistical results. Contribution map analysis explains the individual atomic contributions to the overall activity. This HQSAR model should be useful for the further development of novel structurally related PBR ligands.

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