Publisher： Bentham Science Publishers
E-ISSN： 1873-4316|13|6|787-796
ISSN： 1389-2010
Source： Current Pharmaceutical Biotechnology, Vol.13, Iss.6, 2012-05, pp. : 787-796
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Abstract
During the degradation of heme by the enzyme heme oxygenase (HO), Carbon monoxide (CO) is generated. Although it is considered as a non - significant and potentially toxic waste gas of heme catabolism, CO is a key signaling molecule used to regulate different cardiovascular functions. In this review, we focus the protective roles of CO in vascular injury/disease, which may be important to explore the overall protective roles of HO-1/CO system in the pathogenesis of human vascular disease.
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