Publisher： Bentham Science Publishers
E-ISSN： 1875-6018|5|4|403-412
ISSN： 1871-5214
Source： Anti-Infective Agents in Medicinal Chemistry (Formerly Current Medicinal Chemistry - Anti-Infective Agents), Vol.5, Iss.4, 2006-10, pp. : 403-412
Disclaimer: Any content in publications that violate the sovereignty, the constitution or regulations of the PRC is not accepted or approved by CNPIEC.
Abstract
Invasive fungal infections are a frequent and important complication of modern medicine and remain important causes of morbidity and mortality, particularly in immunocompromised patients. In recent years, the existing antifungal armamentarium has been increased by new drugs and/ or improvement in older drugs. In this review, we summarise the current knowledge of the mechanisms of action and resistance of both new and old antifungal drugs available for the treatment of systemic mycosis. We present in addition, a summary of the results of our studies concerning the mechanism of action of antifungal agents and detection of in vitro resistance of some important human fungal pathogens.
Related content
Access to resources
Recommend
Molecular aspects of azole antifungal action and resistance
Drug Resistance Updates, Vol. 2, Iss. 6, 1999-12 ,pp. :