TRPV1 and TRPA1 in Pulmonary Vagal Afferents and their Relations to Airway Sensitivity

E-ISSN： 1875-614x|10|1|18-30

ISSN： 1871-5230

Source： Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry (Formerly Current Medicinal Chemistry - Anti-Inflammatory and Anti-Allergy Agents), Vol.10, Iss.1, 2011-02, pp. : 18-30

Disclaimer: Any content in publications that violate the sovereignty, the constitution or regulations of the PRC is not accepted or approved by CNPIEC.

Previous Menu Next

Abstract

In the last 15 years, studies of transient receptor potential (TRP) channels have significantly extended our knowledge about the molecular basis of sensory function in pulmonary vagal afferents. In particular, TRPV1 and TRPA1 channels are unique cellular sensors for a wide range of inflammatory mediators and noxious irritants. These channels act as the molecular integrator of multiple nociceptive stimuli and are involved in multiple cellular functions, ranging from transduction of sensory signals to the release of neuropeptides in pulmonary vagal afferents. Increased activity of TRPV1 channels is now recognized as a cause of airway hypersensitivity in inflammatory airway diseases. In this review, we summarize current knowledge about the activation mechanisms of TRPV1 and TRPA1, and discuss the possible functional implications of TRPV1 and TRPA1 in human physiology and pathophysiology, such as the cough reflex and hypersensitivity.