Publisher： Bentham Science Publishers
E-ISSN： 1875-5402|16|10|851-857
ISSN： 1386-2073
Source： Combinatorial Chemistry & High Throughput Screening, Vol.16, Iss.10, 2013-12, pp. : 851-857
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Abstract
A simple, clean and rapid one-pot three component, microwave-assisted synthesis of pyrrolo[1,2-c]pyrimidine derivatives starting from various substituted pyrimidines, 2-bromoacetophenones and nonsymmetrical, electron deficient alkynes in 1,2-epoxybutane which acts both as solvent and acid scavenger is reported. This one-pot three component synthesis implies short reaction times being at the same time highly cost-effective and environmental friendly.
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