Design, Synthesis and In Vitro Anti-Mycobacterial Activity of Chromene Fused Cytosine and Uracil Analogues

Publisher: Bentham Science Publishers

E-ISSN: 2211-3533|11|1|41-47

ISSN: 2211-3525

Source: Anti-Infective Agents, Vol.11, Iss.1, 2013-01, pp. : 41-47

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Abstract

A series of chromene fused cytosine and uracil were prepared by the condensation of thiourea or carbon disulphide with 2-amino-7,7-dimethyl-5-oxo-4-(substituted phenyl)-5,6,7,8-tetrahydro-4H-chromene-3-carbonitrile. The newly synthesized compounds were characterized by IR, 1H-NMR, Elemental analysis and some representative 13C-NMR and Mass spectra. All the title compounds were evaluated for antitubercular and antimicrobial activities against various mycobacterial, bacterial and fungal strains. Some of the compounds have shown promising antimicrobial and antitubercular activity while others were inactive.