

Publisher: John Wiley & Sons Inc
E-ISSN: 1540-8183|28|4|339-347
ISSN: 0896-4327
Source: JOURNAL OF INTERVENTIONAL CARDIOLOGY, Vol.28, Iss.4, 2015-08, pp. : 339-347
Disclaimer: Any content in publications that violate the sovereignty, the constitution or regulations of the PRC is not accepted or approved by CNPIEC.
Abstract
ObjectivesTo determine the impact of percutaneous coronary intervention (PCI) performed at the same time of the peak concentration of rosuvastatin to reduce periprocedural myocardial infarction (PMI).BackgroundPrior studies suggest that a high dose of statin before PCI reduce periprocedural myocardial infarction. However, there is no information regarding the elective PCI performed at the time of the peak of statin concentration to reduce PMI.MethodsFrom 2001 to 2013, at a single center in Brazil we enrolled 544 patients who underwent elective PCI and after exclusions for baseline biases in clinical and angiographic characteristics, yielding 528 patients, we prospectively randomly assigned them to either a high loading dose of Rosuvastatin before PCI (n = 264) or standard treatment (n = 264). After exclusions for biases in procedural characteristics a total of 487 patients underwent to end points analysis. The primary outcome was the incidence of MB fraction of creatine kinase (CK‐MB) greater than three times the upper limit of normal.ResultsThe primary end point occurred in 7.6% in the rosuvastatin and 4.8% in the control group (P = 0.200). There was a higher incidence in elevation of CK‐MB than normal baseline in the rosuvastatin (67.1% vs 59.2%, P = 0.701). There was no difference in major adverse event (0% in the rosuvastatin group vs 0.8% in control).
Related content


CATHETERIZATION AND CARDIOVASCULAR INTERVENTIONS, Vol. 85, Iss. 4, 2015-03 ,pp. :




CARDIOVASCULAR THERAPEUTICS (ELECTRONIC), Vol. 33, Iss. 2, 2015-04 ,pp. :

