Comorbid alcohol dependence disorder may be related to aldehyde dehydrogenase 2 (ALDH2) and alcohol dehydrogenase 1B (ADH1B) in bipolar II disorder, but only to ALDH2 in bipolar I disorder, in Han Chinese

Publisher： John Wiley & Sons Inc

E-ISSN： 1399-5618|17|5|536-542

ISSN： 1398-5647

Source： BIPOLAR DISORDERS (ELECTRONIC), Vol.17, Iss.5, 2015-08, pp. : 536-542

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Abstract

ObjectivesA high prevalence rate of bipolar disorder (BP) comorbid with alcohol dependence (AD) (BP+AD) in Western patients with BP has been reported, but whether this is true for Han Chinese with BP is uncertain. We explored the prevalence of BP+AD in a Han Chinese population with BP, and investigated the effect of alcohol‐metabolizing genotypes on bipolar I disorder (BP‐I) + AD and bipolar II disorder (BP‐II) + AD.MethodsHealthy controls (HCs) (n = 672) and 18‐ to 65‐year‐old patients with BP (BP‐I: n = 530; BP‐II: n = 788) were recruited. Patients with any other major or minor mental illnesses, neurological disorders, or organic mental disorders were excluded. A polymerase chain reaction and restriction fragment length polymorphism analysis was used to determine genotypes for alcohol dehydrogenase 1B (ADH1B) and aldehyde dehydrogenase 2 (ALDH2), two alcohol‐metabolizing enzymes.ResultsAD comorbidity rates were 11.7% with BP‐I and 17.1% with BP‐II. Significantly fewer patients with BP not comorbid with AD (BP–AD) carried the AHD1B*1 allele than did the HCs. Logistic regression analysis showed a main effect of ALDH2*1/*1 only in the BP‐I–AD group. In BP+AD patients, logistic regression analysis showed main effects of ALDH2*1/*1 and ADH1B*1/*1 only in the BP‐II+AD group.ConclusionsHaving BP‐II+AD may be related to ALDH2 and ADH1B, but having BP‐I+AD may be related only to ALDH2. We conclude that ALDH2 and ADH1B have different effects in Han Chinese patients with BP‐I+AD and BP‐II+AD.