BIOCHEMICAL ANALYSES OF STRATUM CORNEUM IN HYPERKERATOSIS LENTICULARIS PERSTANS

E-ISSN： 1346-8138|9|6|473-479

ISSN： 0385-2407

Source： THE JOURNAL OF DERMATOLOGY, Vol.9, Iss.6, 1982-12, pp. : 473-479

Disclaimer: Any content in publications that violate the sovereignty, the constitution or regulations of the PRC is not accepted or approved by CNPIEC.

Previous Menu Next

Abstract

ABSTRACTThe stratum corneum obtained from keratotic papules of hyperkeratosis lenticularis perstans was fractionated into keratin filamentous, water soluble, and membraneous fractions. SDS‐gel electrophoresis was used to examine the keratin filamentous and soluble fractions, and amino acid analysis was employed for all fractions.Electrophoresis of the keratin filamentous fraction revealed no remarkable changes in the pattern of gel bands, compared with normal controls. On the other hand, the pattern observed in the water soluble fraction showed a decrease in the number and intensity of staining bands with molecular weights within the range of 8,000–10,000.In the amino acid analysis, the half‐cystine contents of the patients' membraneous fractions were remarkably lower than those of normal membraneous fractions. Additionally, ornithine and citrulline, which are not usually found as components of protein, were determined to be moderately high in all fractions.