Publisher： John Wiley & Sons Inc
E-ISSN： 1346-8138|21|4|259-263
ISSN： 0385-2407
Source： THE JOURNAL OF DERMATOLOGY, Vol.21, Iss.4, 1994-04, pp. : 259-263
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Abstract
AbstractA 62‐year‐old female with histiocytosis X presented with a vulvar ulcer. Multiple osteolytic lesions were later detected. Histological examination of the ulcerated skin showed diffuse proliferation of histiocytic cells with folded nuclei and pale eosinophilic cytoplasm. Immunohistochemistry revealed S100 protein and vimentin as well as CD1a, CD4, and HLA‐DR antigens in the proliferating cells. Electron microscopy demonstrated Birbeck granules in the cytoplasm of the cells. The patient was successfully treated by complete surgical excision of the ulcer followed by radiotherapy for recurrent vulvar erythema.
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