Publisher： John Wiley & Sons Inc
E-ISSN： 1532-5415|18|5|370-377
ISSN： 0002-8614
Source： JOURNAL OF AMERICAN GERIATRICS SOCIETY, Vol.18, Iss.5, 1970-05, pp. : 370-377
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Abstract
Abstract: Isoniazid resistance developed after one to eleven years of clinical and bacteriologic quiescence in 13 once‐responsive tuberculous patients. A study of the case material disclosed that all but one of the patients had interrupted the initial antituberculosis chemotherapy soon after their sputum samples had become negative. Also, most of the patients had had cavitary lesions that contained large bacterial populations.Residual pulmonary foci of previously dormant tubercle bacilli were likely sources of their isoniazid‐resistant superinfections. Disabled by severe personality disorders and unable to comprehend the gravity of their illnesses, these patients had interrupted chemotherapy, apparently before the medication and their own defense mechanisms had effectively repressed the isoniazid‐resistant mutants in the bacterial population.
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